Synthesis of Optically Active endo, endo Bicyclo[2.2.2]octane-2,5- diol, Bicyclo[2.2.2]octan-2,5-dione and Related Compounds

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Bibtex

@article{c0e8bff6792a4222b0a96d5b35c7a59d,
title = "Synthesis of Optically Active endo, endo Bicyclo[2.2.2]octane-2,5- diol, Bicyclo[2.2.2]octan-2,5-dione and Related Compounds",
abstract = "Optically active C-2-symmetric (1S,2S,4S,5S)-bicyclo[2.2.2]octane-2,5-diol ((+)-12; 98{\%} ee) and several selectivity protected optically active intermediates useful for synthetic transformations were synthesized via a 1,2-carbonyl transposition route starting from the easily available optically active (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octan-2-one ((-)-2). The synthetic route also allowed the preparation of optically active (1S,4S)-bicyclo[2.2.2]octane-2,5-dione ((+)-14; 98{\%} ee).",
author = "Fredrik Almqvist and Niklas Ekman and Torbj{\"o}rn Frejd",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)",
year = "1996",
doi = "10.1021/jo9601167",
language = "English",
volume = "61",
pages = "3794--3798",
journal = "Journal of Organic Chemistry",
issn = "1520-6904",
publisher = "The American Chemical Society (ACS)",
number = "11",

}