Synthesis of the Bioactive Benzochromenes Pulchrol and Pulchral, Metabolites of Bourreria pulchra

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Abstract

The parasites Leshmania mexicana and Trypanosoma cruzi cause serious health problems, and few efficient treatments are available. Recently, the two benzochromenes pulchrol (1) and pulchral (2) were reported from the roots of Bourreria pulchra, and especially 1 but also 2 was found to be active towards the parasites. In this paper, we present a total synthesis of 1 and 2 to facilitate their biological evaluation. The synthesis is mild, short, and high yielding and suitable for a structure-activity relationship study.

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Subject classification (UKÄ) – MANDATORY

  • Chemical Sciences

Keywords

  • Total synthesis, Natural products, Bioactive metabolites, Cross-coupling, Oxygen heterocycles
Original languageEnglish
Pages (from-to)1594-1596
JournalEuropean Journal of Organic Chemistry
Volume2014
Issue number8
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes