Systematic classification of primary immunodeficiencies based on clinical, pathological, and laboratory parameters.

Research output: Contribution to journalArticle

Abstract

The classification of diseases has several important applications ranging from diagnosis and choice of treatment to demographics. To date, classifications have been successfully created manually, often within international consortia. Some groups of diseases, such as primary immunodeficiencies (PIDs), are especially hard to nosologically cluster due, on one hand, to the presence of a wide variety of disorders and, in contrast, because of overlapping characteristics. More than 200 PIDs affecting components of the innate and adaptive immune systems have been described. Clinical, pathological, and laboratory characteristics were collected and used to group PIDs. A consensus of at least five independent methods provided a novel classification of 11 groups, which revealed previously unknown features and relationships of PIDs. Comparison of the classification to independent features, including the severity and therapy of the diseases, functional classification of proteins, and network vulnerability, indicated a strong statistical support. The method can be applied to any group of diseases.

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Authors
External organisations
  • External Organization - Unknown
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area

Keywords

  • Classification: methods, Immunologic Deficiency Syndromes: classification
Original languageEnglish
Pages (from-to)7569-7575
JournalJournal of immunology (Baltimore, Md. : 1950)
Volume183
Issue number11
Publication statusPublished - 2009
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes