TEDDY- The environmental determinants of diabetes in the young - An observational clinical trial

Research output: Contribution to journalArticle

Abstract

The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.

Details

Authors
  • William A. Hagopian
  • Åke Lernmark
  • Marian J. Rewers
  • Olli G. Simell
  • Jin-Xiong She
  • Anette G. Ziegler
  • Jeffrey P. Krischer
  • Beena Akolkar
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes

Keywords

  • type 1 diabetes, islet autoantibodies, HLA, virus
Original languageEnglish
Pages (from-to)320-326
JournalAnnals of the New York Academy of Sciences
Volume1079
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes