Temperature and pH Controlled Self-Assembly of a Protein-Polymer Biohybrid
Research output: Contribution to journal › Article
Abstract
A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer bioconjugate is able to self-assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin-based stimuli-responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a convenient means to preparing amelogenin-based functional biohybrid materials.
Details
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Research areas and keywords | Subject classification (UKÄ) – MANDATORY
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Original language | English |
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Article number | 1700597 |
Journal | Macromolecular Chemistry and Physics |
Volume | 219 |
Issue number | 7 |
Early online date | 2018 Jan 30 |
Publication status | Published - 2018 |
Publication category | Research |
Peer-reviewed | Yes |
Related research output
Research output: Thesis › Doctoral Thesis (compilation)