The age and genomic integrity of neurons after cortical stroke in humans.

Research output: Contribution to journalArticle

Abstract

It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.

Details

Authors
  • Hagen B Huttner
  • Olaf Bergmann
  • Mehran Salehpour
  • Attila Rácz
  • Jemal Tatarishvili
  • Emma Lindgren
  • Tamás Csonka
  • László Csiba
  • Tibor Hortobágyi
  • Gábor Méhes
  • Beata Werne Solnestam
  • Sofia Zdunek
  • Christian Scharenberg
  • Lena Ström
  • Patrik Ståhl
  • Benjamin Sigurgeirsson
  • Andreas Dahl
  • Stefan Schwab
  • Göran Possnert
  • Samuel Bernard
  • Joakim Lundeberg
  • Jonas Frisén
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
Original languageEnglish
Pages (from-to)801-803
JournalNature Neuroscience
Volume17
Issue number6
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Neurology, Lund (013027000)