The aminoterminal-type-III procollagen pepetide and proteoglycans in serum and synovial fluid in patients with rheumatoid arthritis or reactive arthritis.

Research output: Contribution to journalArticle

Abstract

The concentrations of aminoterminal-type-III procollagen (procollagen N-) peptide, and of proteoglycans were measured in knee-joint synovial fluid and serum from patients with rheumatoid arthritis or reactive arthritis. All synovial fluids contained large amounts of intact propeptide. The synovial fluid: serum propeptide ratios were high, suggesting local propeptide liberation. A correlation was demonstrated between the propeptide concentration in synovial fluid and in serum. In rheumatoid arthritis, the propeptide concentration in synovial fluid was related to local inflammatory activity, and the serum concentration was correlated with the presence of nonspecific markers of inflammation. The presence of smaller propeptide fragments in synovial fluid indicated that some degradation occurred locally. The local metabolic changes were most prominent in patients with joint erosions. Patients with nonerosive rheumatoid arthritis and reactive arthritis had similar synovial fluid propeptide concentrations. The proteoglycan content of synovial fluid was inversely related to the degree of joint destruction, and was highest in patients with reactive arthritis. No correlation was observed between the concentrations of propeptide and proteoglycan in synovial fluid. Intraarticular glucocorticoid injection reduced the levels of propeptide and proteoglycan in synovial fluid

Details

Authors
  • Kim Hörslev-Pedersen
  • Tore Saxne
  • D Haar
  • BS Thomsen
  • KD Bentsen
  • Peter Junker
  • Ib Lorenzen
Organisations
External organisations
  • University of Copenhagen
  • King Christian the Xth Hospital
  • Copenhagen University Hospital
  • University of Southern Denmark
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Rheumatology and Autoimmunity

Keywords

  • Arthritis, Rheumatoid/drug therapy, Proteoglycans/analysis, Prospective studies
Original languageEnglish
Pages (from-to)1-9
JournalRheumatology International
Volume8
Publication statusPublished - 1988
Publication categoryResearch
Peer-reviewedYes