The association between smoking and knee osteoarthritis in a cohort of Danish patients undergoing knee arthroscopy

Research output: Contribution to journalArticle

Abstract

Background: It has been suggested that smoking is associated with reduced risk of knee osteoarthritis (OA). However, supplementary studies are needed to further investigate any such potential association. Thus, our aim was to examine the relationship between smoking and early or more established knee OA in a cohort of relatively young patients with meniscal tears. Methods: This cross-sectional study included 620 participants from the Knee Arthroscopy Cohort Southern Denmark (KACS) undergoing knee arthroscopy for a meniscal tear (mean age 49.2 (18.0-76.8) years). Recruitment of patients was performed between February 1, 2013, and January 31, 2015, at four different hospitals in Denmark. We defined early or more established knee OA as the combination of patient-reported frequent knee pain, degenerative meniscal tissue and presence of cartilage defects assessed by the operating surgeons. The relationship between smoking status and knee OA was examined by risk ratio (RR) with a 95% confidence interval (CI), estimated from logistic regression adjusted for age, sex, BMI, education, work status and level of physical activity. Results: The prevalence of early or more established knee OA was 37.7% in current smokers and 45.0% in non-smokers. We found no statistically significant association between current smoking and knee OA (adjusted RR 1.09, 95% CI 0.91-1.30). Conclusions: This study found no relationship between current smoking and early or more established knee OA in a cohort of patients undergoing arthroscopic meniscal surgery. Thus, the inverse association between smoking and knee OA that has been suggested by previous studies was not confirmed.

Details

Authors
  • Marianne Bakke Johnsen
  • Kenneth Pihl
  • Nis Nissen
  • Rasmus Reinholdt Sørensen
  • Uffe Jørgensen
  • Martin Englund
  • Jonas Bloch Thorlund
Organisations
External organisations
  • University of Oslo
  • Oslo university hospital
  • University of Southern Denmark
  • Lillebaelt Hospital
  • Odense University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Orthopedics

Keywords

  • Knee arthroscopy, Knee osteoarthritis, Meniscal tear, Risk factor, Smoking
Original languageEnglish
Article number141
JournalBMC Musculoskeletal Disorders
Volume20
Issue number1
Publication statusPublished - 2019 Apr
Publication categoryResearch
Peer-reviewedYes