The association between smoking and knee osteoarthritis in a cohort of Danish patients undergoing knee arthroscopy

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The association between smoking and knee osteoarthritis in a cohort of Danish patients undergoing knee arthroscopy. / Johnsen, Marianne Bakke; Pihl, Kenneth; Nissen, Nis; Sørensen, Rasmus Reinholdt; Jørgensen, Uffe; Englund, Martin; Thorlund, Jonas Bloch.

In: BMC Musculoskeletal Disorders, Vol. 20, No. 1, 141, 04.2019.

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Johnsen, Marianne Bakke ; Pihl, Kenneth ; Nissen, Nis ; Sørensen, Rasmus Reinholdt ; Jørgensen, Uffe ; Englund, Martin ; Thorlund, Jonas Bloch. / The association between smoking and knee osteoarthritis in a cohort of Danish patients undergoing knee arthroscopy. In: BMC Musculoskeletal Disorders. 2019 ; Vol. 20, No. 1.

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TY - JOUR

T1 - The association between smoking and knee osteoarthritis in a cohort of Danish patients undergoing knee arthroscopy

AU - Johnsen, Marianne Bakke

AU - Pihl, Kenneth

AU - Nissen, Nis

AU - Sørensen, Rasmus Reinholdt

AU - Jørgensen, Uffe

AU - Englund, Martin

AU - Thorlund, Jonas Bloch

PY - 2019/4

Y1 - 2019/4

N2 - Background: It has been suggested that smoking is associated with reduced risk of knee osteoarthritis (OA). However, supplementary studies are needed to further investigate any such potential association. Thus, our aim was to examine the relationship between smoking and early or more established knee OA in a cohort of relatively young patients with meniscal tears. Methods: This cross-sectional study included 620 participants from the Knee Arthroscopy Cohort Southern Denmark (KACS) undergoing knee arthroscopy for a meniscal tear (mean age 49.2 (18.0-76.8) years). Recruitment of patients was performed between February 1, 2013, and January 31, 2015, at four different hospitals in Denmark. We defined early or more established knee OA as the combination of patient-reported frequent knee pain, degenerative meniscal tissue and presence of cartilage defects assessed by the operating surgeons. The relationship between smoking status and knee OA was examined by risk ratio (RR) with a 95% confidence interval (CI), estimated from logistic regression adjusted for age, sex, BMI, education, work status and level of physical activity. Results: The prevalence of early or more established knee OA was 37.7% in current smokers and 45.0% in non-smokers. We found no statistically significant association between current smoking and knee OA (adjusted RR 1.09, 95% CI 0.91-1.30). Conclusions: This study found no relationship between current smoking and early or more established knee OA in a cohort of patients undergoing arthroscopic meniscal surgery. Thus, the inverse association between smoking and knee OA that has been suggested by previous studies was not confirmed.

AB - Background: It has been suggested that smoking is associated with reduced risk of knee osteoarthritis (OA). However, supplementary studies are needed to further investigate any such potential association. Thus, our aim was to examine the relationship between smoking and early or more established knee OA in a cohort of relatively young patients with meniscal tears. Methods: This cross-sectional study included 620 participants from the Knee Arthroscopy Cohort Southern Denmark (KACS) undergoing knee arthroscopy for a meniscal tear (mean age 49.2 (18.0-76.8) years). Recruitment of patients was performed between February 1, 2013, and January 31, 2015, at four different hospitals in Denmark. We defined early or more established knee OA as the combination of patient-reported frequent knee pain, degenerative meniscal tissue and presence of cartilage defects assessed by the operating surgeons. The relationship between smoking status and knee OA was examined by risk ratio (RR) with a 95% confidence interval (CI), estimated from logistic regression adjusted for age, sex, BMI, education, work status and level of physical activity. Results: The prevalence of early or more established knee OA was 37.7% in current smokers and 45.0% in non-smokers. We found no statistically significant association between current smoking and knee OA (adjusted RR 1.09, 95% CI 0.91-1.30). Conclusions: This study found no relationship between current smoking and early or more established knee OA in a cohort of patients undergoing arthroscopic meniscal surgery. Thus, the inverse association between smoking and knee OA that has been suggested by previous studies was not confirmed.

KW - Knee arthroscopy

KW - Knee osteoarthritis

KW - Meniscal tear

KW - Risk factor

KW - Smoking

U2 - 10.1186/s12891-019-2518-z

DO - 10.1186/s12891-019-2518-z

M3 - Article

VL - 20

JO - BMC Musculoskeletal Disorders

T2 - BMC Musculoskeletal Disorders

JF - BMC Musculoskeletal Disorders

SN - 1471-2474

IS - 1

M1 - 141

ER -