The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

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A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.


  • Niels Weinhold
  • David C. Johnson
  • Daniel Chubb
  • Bowang Chen
  • Fay J. Hosking
  • Peter Broderick
  • Yussanne P. Ma
  • Sara E. Dobbins
  • Dirk Hose
  • Brian A. Walker
  • Faith E. Davies
  • Martin F. Kaiser
  • Ni L. Li
  • Walter A. Gregory
  • Graham H. Jackson
  • Mathias Witzens-Harig
  • Kai Neben
  • Per Hoffmann
  • Markus M. Noethen
  • Thomas W. Muehleisen
  • Lewin Eisele
  • Fiona M. Ross
  • Anna Jauch
  • Hartmut Goldschmidt
  • Richard S. Houlston
  • Gareth J. Morgan
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Public Health, Global Health, Social Medicine and Epidemiology
Original languageEnglish
Pages (from-to)522-525
JournalNature Genetics
Issue number5
Publication statusPublished - 2013
Publication categoryResearch