The β-cell capacity for insulin secretion in microdissected pancreatic islets from obese-hyperglycemic mice
Research output: Contribution to journal › Article
The pancreatic islets in obese-hyperglycemic mice display a normal response of insulin secretion when stimulated with glucose in vitro. This indicates that the impaired glucose metabolism is due to extra-pancreatic factors rather than to deficient β-cell function. In fact, the pancreas of these mice is a useful source from which to isolate large numbers of mammalian β-cells suitable for studies of the synthesis and secretion of insulin. The very large islets secreted less insulin than the normally sized ones. Whether this can be attributed to a low concentration gradient for insulin in the central part of the large islets or to the presence of α1-cells remains obscure.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Number of pages||7|
|Issue number||2 PART 2|
|Publication status||Published - 1969 Jan 15|