The β-cell capacity for insulin secretion in microdissected pancreatic islets from obese-hyperglycemic mice

Research output: Contribution to journalArticle

Abstract

The pancreatic islets in obese-hyperglycemic mice display a normal response of insulin secretion when stimulated with glucose in vitro. This indicates that the impaired glucose metabolism is due to extra-pancreatic factors rather than to deficient β-cell function. In fact, the pancreas of these mice is a useful source from which to isolate large numbers of mammalian β-cells suitable for studies of the synthesis and secretion of insulin. The very large islets secreted less insulin than the normally sized ones. Whether this can be attributed to a low concentration gradient for insulin in the central part of the large islets or to the presence of α1-cells remains obscure.

Details

Authors
External organisations
  • Umeå University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalLife Sciences
Volume8
Issue number2 PART 2
Publication statusPublished - 1969 Jan 15
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes