The Cell Physiology of Biphasic Insulin Secretion

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Abstract

Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.

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Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
Original languageEnglish
Pages (from-to)72-77
JournalNews in Physiological Sciences
Volume15
Issue number2
Publication statusPublished - 2000
Publication categoryResearch
Peer-reviewedYes