The effect of crystallinity on strength development of alpha-TCP bone substitutes.

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The effect of crystallinity on strength development of alpha-TCP bone substitutes. / Camire, Christopher; Nevsten, Pernilla; Lidgren, Lars; McCarthy, Ian.

In: Journal of Biomedical Materials Research. Part B - Applied Biomaterials, Vol. 79B, No. 1, 2006, p. 159-165.

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TY - JOUR

T1 - The effect of crystallinity on strength development of alpha-TCP bone substitutes.

AU - Camire, Christopher

AU - Nevsten, Pernilla

AU - Lidgren, Lars

AU - McCarthy, Ian

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Polymer and Materials Chemistry (LTH) (011001041), Department of Orthopaedics (Lund) (013028000)

PY - 2006

Y1 - 2006

N2 - Alpha phase tricalcium phosphates (alpha-TCP) were produced using a solid-state reaction method and milled for various periods of time. The resulting four materials were alpha-TCPs, ranging in crystalline content. Powders were exposed to X-ray diffraction for material identification as well as for use in crystallinity and purity calculations. Powder particle size was investigated using laser diffraction. Materials were mixed with 2.5% Na2HPO4 solution to initiate the hydration of alpha-TCP to calcium-deficient hydroxyapatite (CDHA). Isothermal calorimetry was performed to observe thermal response of the powders over a period of time. During the reaction process, at various time points up to 216 h, the material was compression tested to observe strength development. Materials proved to be predominantly alpha phase, while amorphous content determined by XRD varied. Reactivity, as measured by isothermal calorimetry, varied with crystallinity of the alpha-TCP powder. Speed of strength development did not change except for the most finely ground powder. In addition, crystal size of the CDHA was changed only in the product formed from the most highly ground material. It is proposed that increasing reactivity of alpha-TCP cements does not result in a corresponding increase in rate of strength development until there is sufficient supersaturation to produce significant crystal nucleation.

AB - Alpha phase tricalcium phosphates (alpha-TCP) were produced using a solid-state reaction method and milled for various periods of time. The resulting four materials were alpha-TCPs, ranging in crystalline content. Powders were exposed to X-ray diffraction for material identification as well as for use in crystallinity and purity calculations. Powder particle size was investigated using laser diffraction. Materials were mixed with 2.5% Na2HPO4 solution to initiate the hydration of alpha-TCP to calcium-deficient hydroxyapatite (CDHA). Isothermal calorimetry was performed to observe thermal response of the powders over a period of time. During the reaction process, at various time points up to 216 h, the material was compression tested to observe strength development. Materials proved to be predominantly alpha phase, while amorphous content determined by XRD varied. Reactivity, as measured by isothermal calorimetry, varied with crystallinity of the alpha-TCP powder. Speed of strength development did not change except for the most finely ground powder. In addition, crystal size of the CDHA was changed only in the product formed from the most highly ground material. It is proposed that increasing reactivity of alpha-TCP cements does not result in a corresponding increase in rate of strength development until there is sufficient supersaturation to produce significant crystal nucleation.

KW - calcium phosphate

KW - reactivity

KW - calcium-deficient hydroxyapatite

KW - thermal properties/calorimetry

KW - mechanical strength

U2 - 10.1002/jbm.b.30526

DO - 10.1002/jbm.b.30526

M3 - Article

VL - 79B

SP - 159

EP - 165

JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials

JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials

SN - 1552-4981

IS - 1

ER -