The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species: Results from a randomized crossover intervention study in healthy adults

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The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species : Results from a randomized crossover intervention study in healthy adults. / Schmedes, Mette; Balderas, Claudia; Aadland, Eli Kristin; Jacques, Hélène; Lavigne, Charles; Graff, Ingvild Eide; Eng, Øyvin; Holthe, Asle; Mellgren, Gunnar; Young, Jette Feveile; Sundekilde, Ulrik Kræmer; Liaset, Bjørn; Bertram, Hanne Christine.

In: Nutrients, Vol. 10, No. 5, 598, 11.05.2018.

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Schmedes, M, Balderas, C, Aadland, EK, Jacques, H, Lavigne, C, Graff, IE, Eng, Ø, Holthe, A, Mellgren, G, Young, JF, Sundekilde, UK, Liaset, B & Bertram, HC 2018, 'The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species: Results from a randomized crossover intervention study in healthy adults', Nutrients, vol. 10, no. 5, 598. https://doi.org/10.3390/nu10050598

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Schmedes M, Balderas C, Aadland EK, Jacques H, Lavigne C, Graff IE, Eng Ø, Holthe A, Mellgren G, Young JF, Sundekilde UK, Liaset B, Bertram HC. 2018. The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species: Results from a randomized crossover intervention study in healthy adults. Nutrients. 10(5). https://doi.org/10.3390/nu10050598

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Schmedes, Mette ; Balderas, Claudia ; Aadland, Eli Kristin ; Jacques, Hélène ; Lavigne, Charles ; Graff, Ingvild Eide ; Eng, Øyvin ; Holthe, Asle ; Mellgren, Gunnar ; Young, Jette Feveile ; Sundekilde, Ulrik Kræmer ; Liaset, Bjørn ; Bertram, Hanne Christine. / The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species : Results from a randomized crossover intervention study in healthy adults. In: Nutrients. 2018 ; Vol. 10, No. 5.

RIS

TY - JOUR

T1 - The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species

T2 - Nutrients

AU - Schmedes, Mette

AU - Balderas, Claudia

AU - Aadland, Eli Kristin

AU - Jacques, Hélène

AU - Lavigne, Charles

AU - Graff, Ingvild Eide

AU - Eng, Øyvin

AU - Holthe, Asle

AU - Mellgren, Gunnar

AU - Young, Jette Feveile

AU - Sundekilde, Ulrik Kræmer

AU - Liaset, Bjørn

AU - Bertram, Hanne Christine

PY - 2018/5/11

Y1 - 2018/5/11

N2 - The metabolic effects associated with intake of different dietary protein sources are not well characterized. We aimed to elucidate how two diets that varied in main protein sources affected the fasting and postprandial serum metabolites and lipid species. In a randomized controlled trial with crossover design, healthy adults (n = 20) underwent a 4-week intervention with two balanced diets that varied mainly in protein source (lean-seafood versus non-seafood proteins). Nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry analyses were applied to examine the effects of the two diets on serum metabolites. In the fasting state, the lean-seafood diet period, as opposed to the non-seafood diet period, significantly decreased the serum levels of isoleucine and valine, and during the postprandial state, a decreased level of lactate and increased levels of citrate and trimethylamine N-oxide were observed. The non-seafood diet significantly increased the fasting level of 26 lipid species including ceramides 18:1/14:0 and 18:1/23:0 and lysophosphatidylcholines 20:4 and 22:5, as compared to the lean-seafood diet. Thus, the lean-seafood diet decreased circulating isoleucine and valine levels, whereas the non-seafood diet elevated the levels of certain ceramides, metabolites that are associated with insulin-resistance.

AB - The metabolic effects associated with intake of different dietary protein sources are not well characterized. We aimed to elucidate how two diets that varied in main protein sources affected the fasting and postprandial serum metabolites and lipid species. In a randomized controlled trial with crossover design, healthy adults (n = 20) underwent a 4-week intervention with two balanced diets that varied mainly in protein source (lean-seafood versus non-seafood proteins). Nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry analyses were applied to examine the effects of the two diets on serum metabolites. In the fasting state, the lean-seafood diet period, as opposed to the non-seafood diet period, significantly decreased the serum levels of isoleucine and valine, and during the postprandial state, a decreased level of lactate and increased levels of citrate and trimethylamine N-oxide were observed. The non-seafood diet significantly increased the fasting level of 26 lipid species including ceramides 18:1/14:0 and 18:1/23:0 and lysophosphatidylcholines 20:4 and 22:5, as compared to the lean-seafood diet. Thus, the lean-seafood diet decreased circulating isoleucine and valine levels, whereas the non-seafood diet elevated the levels of certain ceramides, metabolites that are associated with insulin-resistance.

KW - Metabolism

KW - Postprandial

KW - Seafood protein

KW - TMAO

UR - http://www.scopus.com/inward/record.url?scp=85046851009&partnerID=8YFLogxK

U2 - 10.3390/nu10050598

DO - 10.3390/nu10050598

M3 - Article

VL - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 5

M1 - 598

ER -