The effect of the anomeric configuration on the micellization of hexadecylmaltoside surfactants

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The effect of the anomeric configuration on the micellization of hexadecylmaltoside surfactants. / Larsson, Johan; Sanchez-Fernandez, Adrian; Mahmoudi, Najet; Barnsley, Lester; Wahlgren, Marie; Nylander, Tommy; Ulvenlund, Stefan.

In: Langmuir, Vol. 35, No. 43, 2019, p. 13904-13914.

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TY - JOUR

T1 - The effect of the anomeric configuration on the micellization of hexadecylmaltoside surfactants

AU - Larsson, Johan

AU - Sanchez-Fernandez, Adrian

AU - Mahmoudi, Najet

AU - Barnsley, Lester

AU - Wahlgren, Marie

AU - Nylander, Tommy

AU - Ulvenlund, Stefan

PY - 2019

Y1 - 2019

N2 - The self-assembly of the two anomeric forms of n-hexadecyl-D-maltopyranoside (denoted α-C16G2 and β-C16G2) has been studied in dilute aqueous solution by means of surface tension measurements, scattering methods (dynamic light scattering, static light scattering, and small-angle X-ray and neutron scattering) and cryo-transmission electron microscopy at different surfactant concentrations and temperatures. Surface tension measurements demonstrate differences in the surfactant adsorption at the air-water interface, where α-C16G2 shows a lower CMC than β-C16G2. Similarly, micelle morphology was found to profoundly depend on anomerism. β-C16G2 preferentially forms very elongated micelles with large persistence lengths, whereas α-C16G2 assembles into smaller micelles for which the structure varies with concentration and temperature. The differences between the two surfactant anomers in terms of self-assembly can be attributed to the interaction between neighboring headgroups. Specifically, β-C16G2 allows for a closer packing in the palisade layer, hence reducing the micelle curvature and promoting the formation of more elongated micelles. Strong intermolecular headgroup interactions may also account for the observed rigidity of the micelles.

AB - The self-assembly of the two anomeric forms of n-hexadecyl-D-maltopyranoside (denoted α-C16G2 and β-C16G2) has been studied in dilute aqueous solution by means of surface tension measurements, scattering methods (dynamic light scattering, static light scattering, and small-angle X-ray and neutron scattering) and cryo-transmission electron microscopy at different surfactant concentrations and temperatures. Surface tension measurements demonstrate differences in the surfactant adsorption at the air-water interface, where α-C16G2 shows a lower CMC than β-C16G2. Similarly, micelle morphology was found to profoundly depend on anomerism. β-C16G2 preferentially forms very elongated micelles with large persistence lengths, whereas α-C16G2 assembles into smaller micelles for which the structure varies with concentration and temperature. The differences between the two surfactant anomers in terms of self-assembly can be attributed to the interaction between neighboring headgroups. Specifically, β-C16G2 allows for a closer packing in the palisade layer, hence reducing the micelle curvature and promoting the formation of more elongated micelles. Strong intermolecular headgroup interactions may also account for the observed rigidity of the micelles.

U2 - 10.1021/acs.langmuir.9b01960

DO - 10.1021/acs.langmuir.9b01960

M3 - Article

VL - 35

SP - 13904

EP - 13914

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 43

ER -