The Emerging Role of Calcium-activated Chloride Channel Regulator 1 in Cancer

Research output: Contribution to journalReview article

Abstract

Calcium-activated chloride channel regulator 1 (CLCA1) belongs to a group of secreted self-cleaving proteins, which activate calcium-dependent chloride channels. CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma. Recently, additional functions of CLCA1 have been unveiled, including its metalloprotease property and involvement in mucus homeostasis and immune modulation. Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer. There is growing interest in utilizing CLCA1 as a diagnostic, prognostic and predictive biomarker, as well as a potential therapeutic target. In this review, the functional role of CLCA1, with a particular focus on cancer, is described.

Details

Authors
Organisations
External organisations
  • The 2nd Affiliated Hospital & Yuying Children's Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • biomarker, Calcium-activated chloride channel regulator 1, cancer, CLCA1, review
Original languageEnglish
Pages (from-to)1661-1666
Number of pages6
JournalAnticancer research
Volume39
Issue number4
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes