The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update

Research output: Contribution to journalArticle

Abstract

Purpose of Review: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. Recent Findings: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. Summary: TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Details

Authors
  • Heikki Hyöty
  • Åke Lernmark
  • William Hagopian
  • Jin-Xiong She
  • Desmond A Schatz
  • Anette G Ziegler
  • Jorma Toppari
  • Beena Akolkar
  • TEDDY Study Group
Organisations
External organisations
  • Skåne University Hospital
  • Turku University Hospital
  • University of Tampere
  • Pirkanmaa Hospital District
  • Pacific Northwest Diabetes Research Institute
  • Augusta University
  • University of Florida
  • Helmholtz Zentrum München
  • University of Turku
  • National Institute of Diabetes and Digestive and Kidney Diseases
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes

Keywords

  • Autoimmunity, Children, Type 1 diabetes
Original languageEnglish
Article number186
JournalCurrent Diabetes Reports
Volume18
Issue number12
Publication statusPublished - 2018
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

Export Date: 14 November 2018