The european hematology association roadmap for european hematology research: A consensus document

Research output: Contribution to journalArticle

Abstract

The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at ∈ European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better fu treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.

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Authors
  • Andreas Engert
  • Carlo Balduini
  • Anneke Brand
  • Bertrand Coiffier
  • Catherine Cordonnier
  • Hartmut Döhner
  • Thom Duyvené De Wit
  • Sabine Eichinger
  • Willem Fibbe
  • Tony Green
  • Fleur De Haas
  • Achille Iolascon
  • Thierry Jaffredo
  • Francesco Rodeghiero
  • Gilles Sall Es
  • Jan Jacob Schuringa
  • Marc André
  • Isabelle Andre-Schmutz
  • Andrea Bacigalupo
  • Pierre Yves Bochud
  • Monique Den Boer
  • Chiara Bonini
  • Clara Camaschella
  • Andrew Cant
  • Maria Domenica Cappellini
  • Mario Cazzola
  • Cristina Lo Celso
  • Meletios Dimopoulos
  • Luc Douay
  • Elaine Dzierzak
  • Hermann Einsele
  • Andrés Ferreri
  • Lucia De Franceschi
  • Philippe Gaulard
  • Berthold Gottgens
  • Andreas Greinacher
  • Paolo Gresele
  • John Gribben
  • Gerald De Haan
  • John Bjarne Hansen
  • Andreas Hochhaus
  • Rezan Kadir
  • Srini Kaveri
  • Valerie Kouskoff
  • Thomas Kühne
  • Paul Kyrle
  • Per Ljungman
  • Georg Maschmeyer
  • Simón Méndez-Ferrer
  • Michael Milsom
  • Christine Mummery
  • Gert Ossenkoppele
  • Alessandro Pecci
  • Flora Peyvandi
  • Sjaak Philipsen
  • Pieter Reitsma
  • José Maria Ribera
  • Antonio Risitano
  • Stefano Rivella
  • Wolfram Ruf
  • Timm Schroeder
  • Marie Scully
  • Gerard Socie
  • Frank Staal
  • Simon Stanworth
  • Reinhard Stauder
  • Stephan Stilgenbauer
  • Hannah Tamary
  • Kim Theilgaard-Mönch
  • Swee Lay Thein
  • Hervé Tilly
  • Marek Trneny
  • William Vainchenker
  • Alessandro Maria Vannucchi
  • Claudio Viscoli
  • Hans Vrielink
  • Hans Zaaijer
  • Alberto Zanella
  • Lello Zolla
  • Jaap Jan Zwaginga
  • Patricia Aguilar Martinez
  • Emile Van Den Akker
  • Shubha Allard
  • Nicholas Anagnou
  • Immacolata Andolfo
  • Jean Christophe Andrau
  • Emanuele Angelucci
  • David Anstee
  • Igor Aurer
  • Hervé Avet-Loiseau
  • Yesim Aydinok
  • Tamam Bakchoul
  • Alessandra Balduini
  • Wilma Barcellini
  • Dominique Baruch
  • André Baruchel
  • Jagadeesh Bayry
  • Celeste Bento
  • Anke Van Den Berg
  • Rosa Bernardi
  • Paola Bianchi
  • Anna Bigas
  • Andrea Biondi
  • Milos Bohonek
  • Dominique Bonnet
  • Peter Borchmann
  • Niels Borregaard
  • Sigrid Brækkan
  • Marcel Van Den Brink
  • Ellen Brodin
  • Lars Bullinger
  • Christian Buske
  • Barbara Butzeck
  • Jörg Cammenga
  • Elias Campo
  • Antonino Carbone
  • Francisco Cervantes
  • Simone Cesaro
  • Pierre Charbord
  • Frans Claas
  • Hannah Cohen
  • Jacqueline Conard
  • Paul Coppo
  • Joan Lluis Vives Corron
  • Lydie Da Costa
  • Frederic Davi
  • Ruud Delwel
  • Irma Dianzani
  • Dragoslav Domanović
  • Peter Donnelly
  • Tadeja Dovč Drnovšek
  • Martin Dreyling
  • Ming Qing Du
  • Carlo Dufour
  • Charles Durand
  • Dimitar Efremov
  • Androulla Eleftheriou
  • Jacques Elion
  • Marieke Emonts
  • Monika Engelhardt
  • Sophie Ezine
  • Fred Falkenburg
  • Remi Favier
  • Massimo Federico
  • Pierre Fenaux
  • Jude Fitzgibbon
  • Robin Foà
  • Lesley Forrester
  • Frederic Galacteros
  • Isabella Garagiola
  • Chris Gardiner
  • Olivier Garraud
  • Christel Van Geet
  • Hartmut Geiger
  • Jan Geissler
  • Ulrich Germing
  • Cedric Ghevaert
  • Domenico Girelli
  • Bertrand Godeau
  • Nicola Gökbuget
  • Hartmut Goldschmidt
  • Anne Goodeve
  • Thomas Graf
  • Giovanna Graziadei
  • Martin Griesshammer
  • Yves Gruel
  • Francois Guilhot
  • Stephan Von Gunten
  • Inge Gyssens
  • Jörg Halter
  • Claire Harrison
  • Cornelis Harteveld
  • Eva Hellström-Lindberg
  • Olivier Hermine
  • Douglas Higgs
  • Peter Hillmen
  • Hans Hirsch
  • Peter Hoskin
  • Gerwin Huls
  • Adlette Inati
  • Peter Johnson
  • Antonis Kattamis
  • Volker Kiefel
  • Marina Kleanthous
  • Hannes Klump
  • Daniela Krause
  • Johanna Kremer Hovinga
  • Georges Lacaud
  • Sébastien Lacroix-Desmazes
  • Judith Landman-Parker
  • Steven Legouill
  • Georg Lenz
  • Marie Von Lilienfeld-Toal
  • Marieke Von Lindern
  • Armando Lopez-Guillermo
  • Enrico Lopriore
  • Miguel Lozano
  • Elizabeth Macintyre
  • Michael Makris
  • Christine Mannhalter
  • Joost Martens
  • Stephan Mathas
  • Axel Matzdorff
  • Alexander Medvinsky
  • Pablo Menendez
  • Anna Rita Migliaccio
  • Malgorzata Mikulska
  • Véronique Minard
  • Carlos Montalbán
  • Mariane De Montalembert
  • Emili Montserrat
  • Pierre Emmanuel Morange
  • Joanne Mountford
  • Martina Muckenthaler
  • Carsten Müller-Tidow
  • Andrew Mumford
  • Bertrand Nadel
  • Jose Tomas Navarro
  • Wassim El Nemer
  • France Noizat-Pirenne
  • Brian O’Mahony
  • Johannes Oldenburg
  • Martin Olsson
  • Robert Oostendorp
  • Antonio Palumbo
  • Francesco Passamonti
  • Roger Patient
  • Regis Peffault De Latour
  • Francoise Pflumio
  • Luca Pierelli
  • Antonio Piga
  • Debra Pollard
  • Marc Raaijmakers
  • John Radford
  • Ralf Rambach
  • A. Koneti Rao
  • Hana Raslova
  • Paolo Rebulla
  • David Rees
  • Vincent Ribrag
  • Anita Rijneveld
  • Sara Rinalducci
  • Tadeusz Robak
  • Irene Roberts
  • Charlene Rodrigues
  • Frits Rosendaal
  • Andreas Rosenwald
  • Simon Rule
  • Roberta Russo
  • Guiseppe Saglio
  • Mayka Sanchez
  • Rüdiger E. Scharf
  • Peter Schlenke
  • Jorge Sierra
  • Cynthia So-Osman
  • José Manuel Soria
  • Kostas Stamatopoulos
  • Bernd Stegmayr
  • Henk Stunnenberg
  • Dorine Swinkels
  • João Pedro Taborda Barata
  • Tom Taghon
  • Ali Taher
  • Evangelos Terpos
  • Jecko Thachil
  • Jean Daniel Tissot
  • Ivo Touw
  • Ash Toye
  • Ralf Trappe
  • Alexandra Traverse-Glehen
  • Sule Unal
  • Sophie Vaulont
  • Vip Viprakasit
  • Umberto Vitolo
  • Richard Van Wijk
  • Agnieszka Wójtowicz
  • Sacha Zeerleder
  • Barbara Zieger
Organisations
External organisations
  • University of Cologne
  • Policlinico San Matteo Pavia Fondazione
  • Leiden University Medical Centre
  • Université Claude Bernard
  • Henri Mondor Hospital
  • University Hospital of Ulm
  • European Hematology Association
  • Medical University of Vienna
  • University of Cambridge
  • University of Naples Federico II
  • Pierre and Marie Curie University
  • Ospedale San Bortolo
  • Lyon Civil Hospital / Hospices Civils de Lyon
  • University of Groningen
  • European Commission
  • Paris Descartes University
  • Ospedale Policlinico San Martino
  • Lausanne University Hospital
  • Erasmus University Medical Center
  • San Raffaele Scientific Institute
  • Great North Children's Hospital
  • University of Milan
  • University of Pavia
  • Imperial College London
  • National and Kapodistrian University of Athens
  • University of Edinburgh
  • Wurzburg University Medical Center
  • University of Verona
  • University of Greifswald
  • University of Perugia
  • Queen Mary University
  • UiT The Arctic University of Norway, Tromsø
  • Universitätsklinikum Jena
  • Royal Free Hospital
  • Institut Gustave Roussy
  • University of Manchester
  • University Children's Hospital
  • Karolinska Institutet
  • Ernst von Bergmann Klinikum
  • German Cancer Research Centre
  • VU University Medical Center
  • Catalan Institute of Oncology
  • Weill Cornell Medical College
  • University of Mainz
  • ETH Zürich
  • Saint-Louis Hospital, Paris
  • John Radcliffe Hospital
  • Medical University of Innsbruck
  • Schneider Children's Medical Center of Israel
  • University of Copenhagen
  • King's College London
  • University of Rouen
  • Charles University in Prague
  • University of Florence
  • University of Genoa
  • Maggiore Hospital Policlinico
  • University of Tuscia
  • Hôpital Saint Eloi
  • Barts Health NHS Trust
  • Institut de Génétique Moléculaire de Montpellier
  • Ospedale Oncologico Armando Businco
  • National Health Service Blood and Transplant
  • University of Zagreb
  • Toulouse University Hospital
  • Ege University
  • University Medicine Greifswald
  • Hôpital universitaire Robert-Debré
  • University Hospital of Coimbra
  • Hospital del Mar Medical Research Institute
  • European Institute of Oncology
  • The Military University Hospital Prague
  • Francis Crick Institute
  • University Hospital of Cologne
  • Memorial Sloan-Kettering Cancer Center
  • University Hospital of North Norway
  • European Federation of Associations of Patients with Haemochromatosis
  • Linköping University
  • University of Barcelona
  • CRO (Centro di Riferimento Oncologico) Aviano National Cancer Institute
  • University Hospital Verona
  • Hospital Saint-Antoine
  • University of Turin
  • European Centre for Disease Prevention and Control
  • Radboud Institute for Health Sciences
  • Zavod Republike Slovenije za transfuzijsko medicino
  • World Orthopaedic Concern
  • Gaslini Children's Hospital
  • International Centre for Genetic Engineering and Biotechnology
  • Thalassaemia International Federation
  • Paris Diderot University
  • University Medical Center Freiburg
  • Hôpital Armand Trousseau
  • University of Modena and Reggio Emilia
  • Sapienza University of Rome
  • University of Oxford
  • Jean Monnet University
  • Catholic University of Leuven
  • CML Advocates Network
  • Universitätsklinikum Düsseldorf
  • University Hospital Frankfurt
  • University Hospital Heidelberg
  • University of Sheffield
  • Center for Genomic Regulation (CRG)
  • Mühlenkreiskliniken
  • University Hospital of Tours
  • Poitiers University
  • University of Bern
  • Hasselt University
  • University Hospital Basel
  • Guy's and St Thomas' NHS Foundation Trust
  • University of Leeds
  • University of Basel
  • Mount Vernon Hospital
  • Lebanese American University
  • University of Southampton
  • Universitätsmedizin Rostock
  • Cyprus Institute of Neurology and Genetics
  • University Hospital Essen
  • Georg Speyer Haus - Institute for Tumor biology and Experimental Therapy
  • University of Nantes
  • Universitätsklinikum Münster
  • Hospital Clínic of Barcelona
  • Royal Hallamshire Hospital
  • Radboud University Nijmegen
  • Charité Universitätsmedizin Berlin
  • Caritasclinic Saarbrücken
  • Mount Sinai Hospital
  • MD Anderson Cancer Center Madrid
  • Hopital Necker Enfants Malades
  • Aix-Marseille University
  • University of Glasgow
  • Universitätsklinikum Halle
  • University of Bristol
  • University of the Mediterranean
  • French Blood Services of Brittany
  • European Haemophilia Consortium
  • University Hospital Bonn
  • Technical University of Munich
  • Ospedale di Circolo e Fondazione Macchi
  • National Institutes of Health, United States
  • Institut de recherche en radiobiologie cellulaire et moléculaire (IRCM)
  • Deutsche Leukämie- und Lymphomhilfe (DLH)
  • Temple University
  • University of Paris-Sud
  • King's College Hospital
  • Medical University of Lodz
  • Julius Maximilian University of Würzburg
  • Derriford Hospital
  • Josep Carreras Leukaemia Research Institute (IJC)
  • Heinrich Heine University Düsseldorf
  • Medical University of Graz
  • St. Michael's Hospital
  • Hospital de Sant Pau
  • Institute of Applied Biosciences
  • Umeå University
  • University of Lisbon
  • Ghent University
  • American University of Beirut
  • Manchester Royal Infirmary
  • Centre Hospitalier Lyon Sud
  • Hacettepe University
  • Institut Cochin
  • Mahidol University
  • University Medical Center Utrecht
  • Hopital Hotel-Dieu AP-H
Original languageEnglish
Pages (from-to)115-208
Number of pages94
JournalHaematologica
Volume101
Issue number2
Publication statusPublished - 2016 Feb 1
Publication categoryResearch
Peer-reviewedYes