The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.

Details

Authors
  • Jasper C A Broen
  • Marieke J H Coenen
  • Blanca Rueda
  • Torsten Witte
  • Leonid Padyukov
  • Lars Klareskog
  • Carmen Simeon
  • Norberto Ortego-Centeno
  • Miguel González-Gay
  • Anna Pros
  • Nicholas Hunzelman
  • Gabriela Riemekasten
  • Alexander Kreuter
  • Madelon Vonk
  • Rafaella Scorza
  • Lorenzo Beretta
  • Paulo Airò
  • Piet L C M van Riel
  • Robert Kimberly
  • Javier Martin
  • Jeffrey Edberg
  • Timothy R D J Radstake
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Rheumatology and Autoimmunity
Original languageEnglish
Pages (from-to)446-449
JournalJournal of Rheumatology
Volume38
Issue number3
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes