The future of capsule endoscopy in clinical practice: From diagnostic to therapeutic experimental prototype capsules

Research output: Contribution to journalReview article


Capsule endoscopy (CE) is indicated as a first-line clinical examination for the detection of small-bowel pathology, and there is an ever-growing drive for it to become a method for the screening of the entire gastrointestinal tract (GI). Although CE's main function is diagnosis, the research for therapeutic capabilities has intensified to make therapeutic capsule endoscopy (TCE) a target within reach. This manuscript presents the research evolution of CE and TCE through the last 5 years and describes notable problems, as well as clinical and technological challenges to overcome. This review also reports the state-of-the-art of capsule devices with a focus on CE research prototypes promising an enhanced diagnostic yield (DY) and treatment. Lastly, this article provides an overview of the research progress made in software for enhancing DY by increasing the accuracy of abnormality detection and lesion localisation.


  • Michael D. Vasilakakis
  • Anastasios Koulaouzidis
  • Wojciech Marlicz
  • Dimitris K. Iakovidis
External organisations
  • Royal Infirmary of Edinburgh
  • Pomeranian Medical University
  • University of Thessaly
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Gastroenterology and Hepatology


  • Algorithm, Detection, Diagnostic yield, Drug delivery, Engineering, Therapeutic capsule endoscopy
Original languageEnglish
Pages (from-to)179-193
Number of pages15
JournalPrzeglad Gastroenterologiczny
Issue number3
Publication statusPublished - 2020
Publication categoryResearch