The granulation of a tablet formulation in a high-speed mixer, Diosna P25. Influence on intra-granular porosity and liquid saturation

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Abstract

Intragranular porosity and liquid saturation were influenced by the impeller speed, the loss-on-drying of starch, the added amount of water and the drug concentration. A reduction of the impeller speed and the drug concentration decreased the porosity and increased the liquid saturation. Response surface contours were plotted.

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  • Probability Theory and Statistics
Original languageEnglish
Pages (from-to)1069-1079
JournalDrug Development and Industrial Pharmacy
Volume13
Issue number6
Publication statusPublished - 1987
Publication categoryResearch
Peer-reviewedYes