The influence of environmental factors on clinical pathological changes of patients with immunoglobulin A nephropathy from different areas of China

Research output: Contribution to journalArticle


RESULTS: It was shown that the frequency of the patients with no mucosal infection in the urinary tract was higher in the Guangzhou group, while the frequencies of upper respiratory tract and biliary infections were lower when compared with those in the Xi'an group. Serum uric acid, alexin C3, creatinine and serum cholesterol concentrations were increased in the Guangzhou group, while triglyceride, glomerular filtration rate, and urine red blood cell count level decreased. IgA + IgM + C3 and IgA + IgG + IgM + C3 were found in most patients of the Xi'an group, whereas IgA + C3, IgA + IgM + C3 and IgA were more frequent in the Guangzhou group.

CONCLUSION: It was found that differential environment, life habits and patterns in the two investigated areas obviously may influence the variable characteristics of IgAN patients.

METHODS: Patients who were identified to have primary IgAN by renal biopsy diagnosis were recruited both from Shaanxi province hospital of traditional Chinese medicine and Guangdong province hospital of traditional Chinese medicine. Besides renal histopathology data, a number of clinical and laboratory data were collected.

OBJECTIVES: The effects of regional characteristics of IgAN patients in different areas of China were investigated.


  • Ping Fan
  • Jianmin Song
  • Qun Chen
  • Xiaohong Cheng
  • Xusheng Liu
  • Chuan Zou
  • Bin Xie
External organisations
  • Xi'an Jiaotong University
  • Shanxi Provincial Hospital of Traditional Chinese Medicine
  • Xi'an Central Hospital
  • Guangdong Provincial Hospital of Traditional Chinese Medicine
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology


  • case–control study, clinical manifestations, end-stage renal disease, Glomerulonephritis, IgA nephropathy
Original languageEnglish
Pages (from-to)597-602
Number of pages6
JournalRenal failure
Issue number1
Publication statusPublished - 2018
Publication categoryResearch