The influence of pallidal deep brain stimulation on striatal dopaminergic metabolism in the rat

Research output: Contribution to journalArticle

Abstract

Deep brain stimulation of the globus pallidus internus has been recently shown to alleviate parkinsonian symptoms and levodopa-induced dyskinesias. However, its exact mechanisms of action are unclear. Pallidal neurones are connected via various pathways to the dopaminergic nigrostriatal system. In the present study we investigated the hypothesis that deep brain stimulation of the entopeduncular nucleus (corresponds to the human internal pallidum) affects striatal dopaminergic metabolism in naive and 6-hydroxydopamine (6-OHDA) lesioned rats using microdialysis. Our results show that stimulation of the entopeduncular nucleus does not significantly affect striatal dopamine metabolism (of dopamine, 3, 4-dihdroxyphenylacetic acid and homovanillic acid) in naive and 6-OHDA-lesioned animals. They contrast with our previous observations that deep brain stimulation of the subthalamic nucleus increases striatal dopamine metabolism suggesting differential effects of these nuclei on striatal dopamine metabolism.

Details

Authors
  • Wlodzimierz Meissner
  • G Paul
  • Torsten Reum
  • D. R. Reese
  • Reinhard Sohr
  • R Morgenstern
  • A Kupsch
External organisations
  • Humboldt University of Berlin
Research areas and keywords

Keywords

  • 3,4-Dihydroxyphenylacetic Acid, Animals, Denervation, Dopamine, Electric Stimulation Therapy, Globus Pallidus, Homovanillic Acid, Hydroxyindoleacetic Acid, Male, Neostriatum, Neural Pathways, Oxidopamine, Parkinson Disease, Rats, Rats, Wistar, Journal Article, Research Support, Non-U.S. Gov't
Original languageEnglish
Pages (from-to)149-52
Number of pages4
JournalNeuroscience Letters
Volume296
Issue number2-3
Publication statusPublished - 2000 Dec 22
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes