The involvement of cellular proliferation status in the expression of the human proto-oncogene DEK

Research output: Contribution to journalLetter

Abstract

The role of the DEK protein, involved in the leukemia-associated fusion protein DEK-CAN, is not yet known. In this study, we show a higher expression of DEK mRNA in immature cells than in mature cells. Furthermore, a correlation between DEK expression and cell proliferation was demonstrated, suggesting that DEK plays a role in the proliferation of hematopoietic cells and raising the question of whether the DEK-CAN fusion protein might perturb regulation of proliferation in leukemic cells.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • leukemia, DEK, proliferation
Original languageEnglish
Pages (from-to)268-269
JournalHaematologica
Volume91
Issue number2
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedNo