The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation.

Research output: Contribution to journalArticle

Abstract

The activated forms of the complement lectin pathway (LP) proteases MASP-1 and -2 are able to cleave the coagulation factors prothrombin, fibrinogen, factor XIII and TAFI in vitro. In vivo studies also show that MASP-1 is involved in thrombogenesis, OBJECTIVES: To clarify the not yet identified mechanisms involved in triggering activation of the LP during thrombotic reactions.

Details

Authors
  • Huda Kozarcanin
  • Christian Lood
  • Lea Munthe-Fog
  • Kerstin Sandholm
  • Osama A Hamad
  • Anders Bengtsson
  • Mikkel-Ole Skjoedt
  • Markus Huber-Lang
  • Peter Garred
  • Kristina N Ekdahl
  • Bo Nilsson
Organisations
External organisations
  • Uppsala University
  • University of Copenhagen
  • Linnaeus University
  • University Hospital of Ulm
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology
Original languageEnglish
Pages (from-to)531-545
JournalJournal of Thrombosis and Haemostasis
Volume14
Issue number3
Early online date2015 Nov 28
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes