The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases

Research output: Contribution to journalArticle

Abstract

Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.

Details

Authors
Organisations
External organisations
  • Warsaw University of Life Sciences
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology
  • Other Clinical Medicine

Keywords

  • Bacterial effectors, Mitochondrial carriers, Proteases, Structure prediction
Original languageEnglish
Article numbere3849
JournalPeerJ
Volume2017
Issue number9
Publication statusPublished - 2017
Publication categoryResearch
Peer-reviewedYes