The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

Research output: Contribution to journalArticle

Abstract

A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

Details

Authors
  • Evald Rosengren
  • Pierre Åman
  • Sofia Thelin
  • Christer Hansson
  • Stefan Ahlfors
  • Peter Björk
  • Lars Jacobsson
  • Hans Rorsman
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biological Sciences

Keywords

  • Macrophage migration inhibitory factor, Phenylpyruvate tautomerase, Dopachrome tautomerase, Cytokine
Original languageEnglish
Pages (from-to)85-88
JournalFEBS Letters
Volume417
Issue number1
Publication statusPublished - 1997
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Dermatology and Venereology (Lund) (013006000), Department of Experimental Medical Science (013210000)