The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

Research output: Contribution to journalArticle


title = "The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase",
abstract = "A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.",
keywords = "Macrophage migration inhibitory factor, Phenylpyruvate tautomerase, Dopachrome tautomerase, Cytokine",
author = "Evald Rosengren and Pierre {\AA}man and Sofia Thelin and Christer Hansson and Stefan Ahlfors and Peter Bj{\"o}rk and Lars Jacobsson and Hans Rorsman",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Dermatology and Venereology (Lund) (013006000), Department of Experimental Medical Science (013210000)",
year = "1997",
doi = "10.1016/S0014-5793(97)01261-1",
language = "English",
volume = "417",
pages = "85--88",
journal = "FEBS Letters",
issn = "1873-3468",
publisher = "Wiley-Blackwell",
number = "1",