The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.

Research output: Contribution to journalArticle

Abstract

One of the major roles of seminal plasma is to provide antimicrobial protection for the spermatozoa in the female reproductive tract. We found that the bactericidal activity of seminal plasma was highest after resolution of the seminal clot and that this antibacterial activity subsequently became greatly diminished. The antibacterial activity was derived from peptides generated by fragmentation of the semenogelins while the semenogelin holoproteins displayed no antibacterial activity. After ejaculation the semenogelin-derived peptides were fragmented to smaller and smaller fragments over time and thereby lost antibacterial activity. This paralleled the loss of antibacterial activity of whole seminal plasma both in vitro and after sexual intercourse. Moreover, the antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH. These data provide novel roles for the resolution of seminal clots and for the high zinc concentration in human seminal plasma.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area
Original languageEnglish
Pages (from-to)3413-3421
JournalJournal of immunology (Baltimore, Md. : 1950)
Volume181
Issue number5
Publication statusPublished - 2008
Publication categoryResearch
Peer-reviewedYes

Related research output

Edström, A., 2010, Lund University. 121 p.

Research output: ThesisDoctoral Thesis (compilation)

View all (1)