The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

Research output: Contribution to journalReview article

Abstract

The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the “A, T, N System” (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.

Details

Authors
  • David S. Knopman
  • Samantha Budd Haeberlein
  • Maria C. Carrillo
  • James A. Hendrix
  • Geoff Kerchner
  • Richard Margolin
  • Paul Maruff
  • David S. Miller
  • Gary Tong
  • Maria B. Tome
  • Melissa E. Murray
  • Peter T. Nelson
  • Mary Sano
  • David L. Sultzer
  • Thomas J. Montine
  • Clifford R. Jack
  • Hartmuth Kolb
  • Ronald C. Petersen
  • Prashanthi Vemuri
  • Megan Zoschg Canniere
  • Julie A. Schneider
  • Susan M. Resnick
  • Gary Romano
  • Argonde Corien van Harten
  • David A. Wolk
  • Lisa J. Bain
  • Eric Siemers
Organisations
External organisations
  • Mayo Clinic Minnesota
  • Biogen, Inc.
  • Alzheimer's Association: Alzheimer's Disease and Dementia
  • Genentech, Inc
  • Pfizer Inc. US
  • European Medicines Agency (EMA)
  • Mayo Clinic Florida
  • University of Kentucky
  • Icahn School of Medicine at Mount Sinai
  • Stanford University
  • Janssen Research & Development LLC
  • F. Hoffmann-La Roche AG
  • Rush University Medical Center Chicago
  • National Institute on Aging, United States
  • VU University Medical Center
  • University of Pennsylvania
  • Lilly Research Laboratories
  • Cogstate Ltd
  • Bracket Global LLC
  • Lundbeck US
  • University of California, Los Angeles
  • No affiliation available (private)
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Alzheimer's disease, Amyloid, Biomarkers, Clinical trials, Neurodegeneration, Tau
Original languageEnglish
Pages (from-to)563-575
Number of pages13
JournalAlzheimer's and Dementia
Volume14
Issue number4
Publication statusPublished - 2018 Apr 1
Publication categoryResearch
Peer-reviewedYes