The new cell irradiation facility at the Lund nuclear probe

Research output: Contribution to journalArticle

Abstract

The CELLION project is directed towards the studies on cellular response to targeted single ions. This paper gives an account of the modifications made at the Lund sub-micron beam line in order to create a Single Ion Hit Facility for biological applications within the CELLION project. The most relevant new feature is the specially developed software used to locate the cells. A program for cell recognition and localization that gives the coordinates of the centre of the cells has been designed. The recognition is made online. A picture taken by a microscope is used as input parameter for the recognition program. Using V79 Chinese hamster cells, the recognition procedure can be done in less than 0.5 s for a picture size of 800 x 600 pixels with approximately 96% efficiency. This paper also reports target accuracy test results and the first non-targeted irradiation procedure performed at the Lund sub-micron beam line. (c) 2007 Elsevier B.V. All rights reserved.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine

Keywords

  • irradiation, single ions, cell, CELLION
Original languageEnglish
Pages (from-to)91-96
JournalNuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Volume260
Issue number1
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes
Event10th International Conference on Nuclear Microprobe Technology and Applications and 2nd International Workshop on Proton Beam Writing - Singapore, Singapore
Duration: 2006 Jul 92006 Jul 14

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007), Division of Infection Medicine (BMC) (013024020)

Related research output

Natalia Arteaga, 2010, Department of Physics, Lund University. 133 p.

Research output: ThesisDoctoral Thesis (compilation)

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