The Non-Motor Symptoms Scale in Parkinson’s disease: Validation and use

Research output: Contribution to journalReview article


The Non-Motor Symptoms Scale (NMSS) was developed and validated in 2007 as the first instrument for the comprehensive assessment of a range of non-motor symptoms in Parkinson's disease (PD). Thirteen years have elapsed since its introduction and extensive international validation with good psychometric attributes has been carried out. Here, we review the validation data of the NMSS and its cross-validity with other scales, and describe the key evidence derived from use of the NMSS in clinical studies. To date, over 100 clinical studies and trials have made use of it as an outcome measure, showing consistent and strong correlations between NMSS burden and health-related quality of life measures. Moreover, the scale has shown to be capable of detecting longitudinal changes in non-motor symptoms, where studies have shown differential changes over time of several of the NMSS domains. The scale has become a key outcome in several randomized clinical trials. Highlighting the prevalence and importance of non-motor symptoms to quality of life in patients with PD, the development of NMSS has also been useful in signposting clinical and biomarker based research addressing non-motor symptoms in PD.


  • Daniel J. van Wamelen
  • Pablo Martinez-Martin
  • Daniel Weintraub
  • Anette Schrag
  • Angelo Antonini
  • Cristian Falup-Pecurariu
  • Per Odin
  • Kallol Ray Chaudhuri
External organisations
  • King's College London
  • CIBER Enfermedades Neurodegenerativas (CIBERNED)
  • Philadelphia Veterans Affairs Medical Center
  • University College London
  • University of Padova
  • Transylvania University Brasov
  • King's College Hospital
  • Radboud University Medical Center
  • University of Pennsylvania
  • Central Hospital Bremerhaven
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)3-12
Number of pages10
JournalActa Neurologica Scandinavica
Issue number1
Early online date2020 Aug 19
Publication statusPublished - 2021 Jan
Publication categoryResearch