The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitors

Research output: Contribution to journalArticle

Abstract

Native γ-trace, a small basic protein present in high concentration in cerebrospinal fluid, semen and neuroendocrine cells, but of unknown biological function, is shown to be a potent inhibitor of the cysteine proteinases papain, ficin, and human cathepsins B, H and L. It proves to be the tightest-binding protein inhibitor of cathepsin B so far discovered. The name cystatin C is proposed for γ-trace to reflect the many similarities in activity and structure to chicken egg-white cystatin and mammalian cystatins A and B. The inhibition constants of cystatin C, taken together with its widespread distribution in human tissues and extracellular fluids, suggest that a physiological function could well be the regulation of cysteine proteinase activity.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Other Basic Medicine
Original languageEnglish
Pages (from-to)631-636
JournalBiochem Biophys Res Commun.
Volume120
Publication statusPublished - 1984
Publication categoryResearch
Peer-reviewedYes