The putative tumor suppressor gene EphA7 is a novel BMI-1 target

Research output: Contribution to journalArticle

Abstract

Bmi1 was originally identified as a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and Arf. It codes for the Polycomb group protein BMI-1 and acts primarily as a transcriptional repressor via chromatin modifications. Although it binds to a large number of genomic regions, the direct BMI-1 target genes described so far do not explain the full spectrum of BMI-1-mediated effects. Here we identify the putative tumor suppressor gene EphA7 as a novel direct BMI-1 target in neural cells and lymphocytes. EphA7 silencing has been reported in several different human tumor types including lymphomas, and our data suggest BMI1 overexpression as a novel mechanism leading to EphA7 inactivation via H3K27 trimethylation and DNA methylation.

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Research areas and keywords

Subject classification (UKÄ)

  • Medical Genetics

Keywords

  • Bmi1, EphA7, neural stem cells, DNA methylation
Original languageEnglish
Pages (from-to)58203-58217
Number of pages15
JournalOncotarget
Volume7
Issue number36
Publication statusPublished - 2016 Sep 6
Publication categoryResearch
Peer-reviewedYes