The release of aggrecan fragments into synovial fluid after joint injury and in osteoarthritis

Research output: Contribution to journalArticle

Abstract

Aggrecan fragments are released from human joint cartilage matrix into joint fluid after injury and in osteoarthritis (OA). The temporal patterns of release agree with changes in synthesis and degradation of aggrecan found in experimental animal models of OA. However, we are far from being able to use these molecular fragments to monitor human OA. The structures of the aggrecan fragments remaining in cartilage, and of those being released into joint fluid after cleavage, are consistent with more than one proteolytic agent being active in human joint cartilage after joint injury and in OA.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Orthopedics

Keywords

  • Aggrecan, Cartilage, Joint injury, Osteoarthritis, Synovial fluid
Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalJournal of Rheumatology
Volume22
Issue numberSUPPL. 43
Publication statusPublished - 1995
Publication categoryResearch
Peer-reviewedYes