The role of human glandular kallikrein 2 for prediction of pathologically organ confined prostate cancer

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The role of human glandular kallikrein 2 for prediction of pathologically organ confined prostate cancer. / Haese, A; Graefen, M; Becker, Charlotte; Noldus, J; Katz, J; Cagiannos, I; Kattan, M; Scardino, PT; Huland, E; Huland, H; Lilja, Hans.

In: The Prostate, Vol. 54, No. 3, 2003, p. 181-186.

Research output: Contribution to journalArticle

Harvard

Haese, A, Graefen, M, Becker, C, Noldus, J, Katz, J, Cagiannos, I, Kattan, M, Scardino, PT, Huland, E, Huland, H & Lilja, H 2003, 'The role of human glandular kallikrein 2 for prediction of pathologically organ confined prostate cancer', The Prostate, vol. 54, no. 3, pp. 181-186. https://doi.org/10.1002/pros.10180

APA

Haese, A., Graefen, M., Becker, C., Noldus, J., Katz, J., Cagiannos, I., Kattan, M., Scardino, PT., Huland, E., Huland, H., & Lilja, H. (2003). The role of human glandular kallikrein 2 for prediction of pathologically organ confined prostate cancer. The Prostate, 54(3), 181-186. https://doi.org/10.1002/pros.10180

CBE

Haese A, Graefen M, Becker C, Noldus J, Katz J, Cagiannos I, Kattan M, Scardino PT, Huland E, Huland H, Lilja H. 2003. The role of human glandular kallikrein 2 for prediction of pathologically organ confined prostate cancer. The Prostate. 54(3):181-186. https://doi.org/10.1002/pros.10180

MLA

Vancouver

Author

Haese, A ; Graefen, M ; Becker, Charlotte ; Noldus, J ; Katz, J ; Cagiannos, I ; Kattan, M ; Scardino, PT ; Huland, E ; Huland, H ; Lilja, Hans. / The role of human glandular kallikrein 2 for prediction of pathologically organ confined prostate cancer. In: The Prostate. 2003 ; Vol. 54, No. 3. pp. 181-186.

RIS

TY - JOUR

T1 - The role of human glandular kallikrein 2 for prediction of pathologically organ confined prostate cancer

AU - Haese, A

AU - Graefen, M

AU - Becker, Charlotte

AU - Noldus, J

AU - Katz, J

AU - Cagiannos, I

AU - Kattan, M

AU - Scardino, PT

AU - Huland, E

AU - Huland, H

AU - Lilja, Hans

PY - 2003

Y1 - 2003

N2 - BACKGROUND. In recent studies serum levels of human glandular kallikrein 2 (hK2) demonstrated significant differences in pathologically organ-confined versus non-organ-confined prostate cancer (Pca). In this study we investigated whether hK2 adds independent information when considered together with traditionally used parameters to predict organ confined (pT2a/b) PCa. METHODS. Serum levels of hK2, total and free prostate-specific antigens (PSA) were obtained one day before radical prostatectomy in 245 consecutive men. These were included with clinical stage and biopsy Gleason grade into univariate analysis and multivariate logistic regression models. RESULTS. pT2a/b PCa was found in n = 148 patients. In univariate analysis all preoperative parameters demonstrated significant association with the presence of pT2a/b PCa. Using multivariate logistic regression model hK2 (P = 0.022), clinical stage (P < 0.0001), and Gleason grade (P < 0.0001) were independent predictors of pT2a/b PCa whereas PSA (P = 0.3) was not. In bootstrap corrected logistic regression based nomograms the addition of hK2 density marginally enhanced predictive accuracy when PSA, PSA density, clinical stage, and Gleason grade were considered (AUC = 0.879 without hK2 density and 0.883 with hK2 density). CONCLUSIONS. hK2 and hK2 density could independently predict pT2a/b PCa. However, improvement in predictive accuracy was marginal when nomograms based on traditional variables were complemented with this serum marker. (C) 2002 Wiley-Liss, Inc.

AB - BACKGROUND. In recent studies serum levels of human glandular kallikrein 2 (hK2) demonstrated significant differences in pathologically organ-confined versus non-organ-confined prostate cancer (Pca). In this study we investigated whether hK2 adds independent information when considered together with traditionally used parameters to predict organ confined (pT2a/b) PCa. METHODS. Serum levels of hK2, total and free prostate-specific antigens (PSA) were obtained one day before radical prostatectomy in 245 consecutive men. These were included with clinical stage and biopsy Gleason grade into univariate analysis and multivariate logistic regression models. RESULTS. pT2a/b PCa was found in n = 148 patients. In univariate analysis all preoperative parameters demonstrated significant association with the presence of pT2a/b PCa. Using multivariate logistic regression model hK2 (P = 0.022), clinical stage (P < 0.0001), and Gleason grade (P < 0.0001) were independent predictors of pT2a/b PCa whereas PSA (P = 0.3) was not. In bootstrap corrected logistic regression based nomograms the addition of hK2 density marginally enhanced predictive accuracy when PSA, PSA density, clinical stage, and Gleason grade were considered (AUC = 0.879 without hK2 density and 0.883 with hK2 density). CONCLUSIONS. hK2 and hK2 density could independently predict pT2a/b PCa. However, improvement in predictive accuracy was marginal when nomograms based on traditional variables were complemented with this serum marker. (C) 2002 Wiley-Liss, Inc.

KW - cancer stage

KW - biochemical predictors of prostate

KW - hK2

KW - prostate-specific antigen

U2 - 10.1002/pros.10180

DO - 10.1002/pros.10180

M3 - Article

VL - 54

SP - 181

EP - 186

JO - Prostate

JF - Prostate

SN - 0270-4137

IS - 3

ER -