The role of PEDF in pancreatic cancer

Research output: Contribution to journalReview article

Abstract

Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy, occurrence of liver metastasis and worse prognosis. In murine models, loss of PEDF is sufficient to induce invasive carcinoma and this phenotype is associated with large lesions characterized by poor differentiation. Lentiviral gene transfer of PEDF has resulted in decreased microvessel density and has inhibited tumor growth. Herein we review the multifunctional role of PEDF in pancreatic cancer and its therapeutic potential.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
  • Cell and Molecular Biology

Keywords

  • Angiogenesis, Autophagy, Fibrosis, Inflammation, Metastasis, Pancreatic Cancer, PEDF, Prognosis, Review, Treatment, Tumor growth
Original languageEnglish
Pages (from-to)3311-3315
Number of pages5
JournalAnticancer research
Volume39
Issue number7
Publication statusPublished - 2019 Jul
Publication categoryResearch
Peer-reviewedYes