The role of therapy in impairing quality of life in dermatological patients: A multinational study

Research output: Contribution to journalArticle


Skin disease and its therapy affect health-related quality of life (HRQoL). The aim of this study was to measure the burden caused by dermatological therapy in 3,846 patients from 13 European countries. Adult outpatients completed questionnaires, including the Dermatology Life Quality Index (DLQI), which has a therapy impact question. Therapy issues were reported by a majority of patients with atopic dermatitis (63.4%), psoriasis (60.7%), prurigo (54.4%), hidradenitis suppurativa (54.3%) and blistering conditions (53%). The largest reduction in HRQoL attributable to therapy, as a percentage of total DLQI, adjusted for confounders, was seen in blistering conditions (10.7%), allergic/ drug reactions (10.2%), psoriasis (9.9%), vasculi-tis/immunological ulcers (8.8%), atopic dermatitis (8.7%), and venous leg ulcers (8.5%). In skin cancer, although it had less impact on HRQoL, the reduction due to therapy was 6.8%. Treatment for skin disease contributes considerably to reducing HRQoL: the burden of dermatological treatment should be considered when planning therapy and designing new dermatological therapies.


  • Flora N. Balieva
  • Andrew Y. Finlay
  • Jörg Kupfer
  • Lucia Tomas Aragones
  • Lars Lien
  • Uwe Gieler
  • Francoise Poot
  • Gregor B.E. Jemec
  • Laurent Misery
  • Lajos Kemeny
  • Francesca Sampogna
  • Henriët Van Middendorp
  • Jon Anders Halvorsen
  • Thomas Ternowitz
  • Jacek C. Szepietowski
  • Nikolay Potekaev
  • Servando E. Marron
  • Ilknur K. Altunay
  • Sam S. Salek
  • Florence J. Dalgard
External organisations
  • Stavanger University Hospital
  • Cardiff University
  • Justus Liebig University Giessen
  • University of Zaragoza
  • University Hospital of Brest
  • University of Szeged
  • Istituto Dermopatico dell'Immacolata (IDI)-IRCCS FLMM
  • Leiden University
  • Wrocław Medical University
  • Innlandet Hospital Trust
  • Skåne University Hospital
  • Inland Norway University of Applied Sciences
  • Hospital Erasme
  • Zealand University Hospital
  • Oslo university hospital
  • University of Oslo
  • Moscow Scientific and Practical Center of Dermatology, Venereology and Cosmetology
  • Russian National Research Medical University
  • Aragon Health Sciences Institute
  • Sisli Etfal Teaching and Research Hospital
  • University of Hertfordshire
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Dermatology and Venereal Diseases


  • Burden of skin disease, Dermatological therapy, DLQI, HRQoL, Quality of life, Therapy burden
Original languageEnglish
Pages (from-to)563-569
Number of pages7
JournalActa Dermato-Venereologica
Issue number6
Publication statusPublished - 2018 Jun 1
Publication categoryResearch
Externally publishedYes