The Salt-Inducible Kinases: Emerging Metabolic Regulators

Research output: Contribution to journalReview article

Abstract

The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation.

Details

Authors
Organisations
External organisations
  • Nestlé
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology

Keywords

  • AMP-activated protein kinase, AMPK, AMPK-related kinase, energy metabolism, gluconeogenesis, LKB1
Original languageEnglish
Pages (from-to)827-840
JournalTrends in Endocrinology and Metabolism
Volume29
Issue number12
Publication statusPublished - 2018
Publication categoryResearch
Peer-reviewedYes