The serotonergic system in L-DOPA-induced dyskinesia: pre-clinical evidence and clinical perspective

Research output: Contribution to journalArticle

Abstract

During the last decade, the serotonergic system has emerged as a key player in the appearance of L-DOPA-induced dyskinesia in animal models of Parkinson’s disease. Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of this complication of long-term L-DOPA treatment in parkinsonian patients. These findings have stimulated efforts to develop new therapies using drugs targeting the malfunctioning serotonin neurons. In this review, we summarize the experimental and clinical data obtained so far and discuss the prospects for further development of this therapeutic strategy.

Details

Authors
Organisations
External organisations
  • University of Cagliari
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Dyskinesia, L-DOPA, Parkinson’s disease, Serotonin, Serotonin autoreceptors
Original languageEnglish
Pages (from-to)1195-1202
JournalJournal of Neural Transmission
Volume125
Issue number8
Publication statusPublished - 2018 Aug
Publication categoryResearch
Peer-reviewedYes