The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease

Research output: Contribution to journalArticle

Abstract

Objectives - To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). Materials and methods -Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of Cognitive Speed (AQT), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and MMSE were administered concurrently. Results-Correlations (rho) between age and AQT processing speed were non-significant, but were significant for ADAS-Cog and Mini Mental State Examination (MMSE). AQT and ADAS-Cog means did not differ significantly between baseline and endpoint. There was a small, significant reduction in MMSE point scores. Measures of stability (Spearman's rho) were moderate-to-high for all tests. Means for subgroups did not differ as a function of medication type. Conclusions - AQT processing speed, ADAS-Cog, and MMSE measures proved stable during the second 6 months of treatment with AChEI.

Details

Authors
  • E. H. Wiig
  • P. Annas
  • H. Basun
  • N. Andreasen
  • L. Lannfelt
  • H. Zetterberg
  • K. Blennow
  • Lennart Minthon
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • treatment, AchEI, Alzheimer's disease, MMSE, ADAS-Cog, AQT, processing speed, longitudinal stability
Original languageEnglish
Pages (from-to)186-193
JournalActa Neurologica Scandinavica
Volume121
Issue number3
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes