The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27

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title = "The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27",
abstract = "The STRIPAK complex has been linked to a variety of biological processes taking place during embryogenesis and development, but its role in cancer has only just started to be defined. Here, we expand on previous work indicating a role for the scaffolding protein STRIP1 in cancer cell migration and metastasis. We show that cell cycle arrest and decreased proliferation are seen upon loss of STRIP1 in MDA-MB-231 cells due to the induction of cyclin dependent kinase inhibitors, including p21 and p27. We demonstrate that p21 and p27 induction is observed in a subpopulation of cells having low DNA damage response and that the p21high/γH2AXlow ratio within single cells can be rescued by depleting MST3&4 kinases. While the loss of STRIP1 decreases cell proliferation and tumor growth, cells treated with low dosage of chemotherapeutics in vitro paradoxically escape therapy-induced senescence and begin to proliferate after recovery. This corroborates with already known research on the dual role of p21 and indicates that STRIP1 also plays a contradictory role in breast cancer, suppressing tumor growth, but once treated with chemotherapeutics, allowing for possible recurrence and decreased patient survival.",
author = "Carmen Rodriguez-Cupello and Monica Dam and Laura Serini and Shan Wang and David Lindgren and Emelie Englund and Pontus Kjellman and H{\aa}kan Axelson and {Garc{\'i}a Mariscal}, Alberto and Chris Madsen",
year = "2020",
month = mar,
day = "17",
doi = "10.3389/fcell.2020.00146",
language = "English",
volume = "8",
journal = "Frontiers in cell and developmental biology",
issn = "2296-634X",
publisher = "Frontiers Media S. A.",