The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey.

Research output: Contribution to journalArticle

Abstract

We investigated the use of Alzheimer's disease (AD) biomarkers in European Alzheimer's Disease Consortium centers and assessed their perceived usefulness for the etiologic diagnosis of mild cognitive impairment (MCI). We surveyed availability, frequency of use, and confidence in diagnostic usefulness of markers of brain amyloidosis (amyloid positron emission tomography [PET], cerebrospinal fluid [CSF] Aβ42) and neurodegeneration (medial temporal atrophy [MTA] on MR, fluorodeoxyglucose positron emission tomography [FDG-PET], CSF tau). The most frequently used biomarker is visually rated MTA (75% of the 37 responders reported using it "always/frequently") followed by CSF markers (22%), FDG-PET (16%), and amyloid-PET (3%). Only 45% of responders perceive MTA as contributing to diagnostic confidence, where the contribution was rated as "moderate". Seventy-nine percent of responders felt "very/extremely" comfortable delivering a diagnosis of MCI due to AD when both amyloid and neuronal injury biomarkers were abnormal (P < .02 versus any individual biomarker). Responders largely agreed that a combination of amyloidosis and neuronal injury biomarkers was a strongly indicative AD signature.

Details

Authors
  • Martina Bocchetta
  • Samantha Galluzzi
  • Patrick Gavin Kehoe
  • Eduardo Aguera
  • Roberto Bernabei
  • Roger Bullock
  • Mathieu Ceccaldi
  • Jean-François Dartigues
  • Alexandre de Mendonça
  • Mira Didic
  • Maria Eriksdotter
  • Olivier Félician
  • Lutz Frölich
  • Hermann-Josef Gertz
  • Merja Hallikainen
  • Steen G Hasselbalch
  • Lucrezia Hausner
  • Isabell Heuser
  • Frank Jessen
  • Roy W Jones
  • Alexander Kurz
  • Brian Lawlor
  • Alberto Lleo
  • Pablo Martinez-Lage
  • Patrizia Mecocci
  • Shima Mehrabian
  • Andreas Monsch
  • Flavio Nobili
  • Agneta Nordberg
  • Marcel Olde Rikkert
  • Jean-Marc Orgogozo
  • Florence Pasquier
  • Oliver Peters
  • Eric Salmon
  • Carmen Sánchez-Castellano
  • Isabel Santana
  • Marie Sarazin
  • Latchezar Traykov
  • Magda Tsolaki
  • Pieter Jelle Visser
  • Gordon Wilcock
  • David Wilkinson
  • Henrike Wolf
  • Görsev Yener
  • Dina Zekry
  • Giovanni B Frisoni
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)195-206
JournalAlzheimer's & Dementia
Volume11
Issue number2
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes