The Value of Induction Chemotherapy for Survival in Patients with Non-small Cell Lung Cancer Treated with Radiotherapy

Research output: Contribution to journalArticle

Abstract

Aim: The aim of the present study was to retrospectively investigate the impact of induction chemotherapy on treatment outcome in patients treated with curatively intended radiotherapy for non-small cell lung cancer (NSCLC). Patients and Methods: Patients with a diagnosed NSCLC that have been subjected to curatively intended irradiation (>= 50 Gy) and treated in an oncology department in Sweden during the years 1990-2000 were included in the study. Operated patients and patients having received concomitant chemotherapy were excluded. The included patients were localised by a manual search of all the oncology departments' medical records and radiation charts. Results: Patients treated with induction chemotherapy (n=79) had a significantly better overall survival compared with patients treated with radiotherapy alone (p=0.0097) in a univariate Cox regression analysis. A platinum/taxane combination produced the greatest survival benefit; hazard ratio=0.49 (95% confidence interval=0.31 to 0.75). Conclusion: We found that patients treated with induction chemotherapy in addition to radiotherapy for NSCLC have a better overall survival than patients treated with radiotherapy alone and that the best results are achieved using a platinum/taxane combination.

Details

Authors
  • Georg Holgersson
  • Martin Sandelin
  • Even Hoye
  • Stefan Bergstrom
  • Roger Henriksson
  • Simon Ekman
  • Jan Nyman
  • Martin Helsing
  • Signe Friesland
  • Ola Brodin
  • Margareta Holgersson
  • Kristina Lamberg Lundstrom
  • Christer Janson
  • Lars Ekberg
  • Charlotte Morth
  • Thomas Blystad
  • Sven-Börje Ewers
  • Britta Loden
  • Michael Bergqvist
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • NSCLC, lung cancer, radiotherapy, predictive value, age
Original languageEnglish
Pages (from-to)1339-1346
JournalAnticancer research
Volume32
Issue number4
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedYes