The water-perfusable tissue fraction of colorectal cancer metastases is increased by the selective PDGF-receptor inhibitor imatinib but not the IL-1 receptor antagonist anakinra, a study using serial dynamic 15O-water PET.
Research output: Contribution to journal › Article
High interstitial fluid pressure (IFP) in colorectal cancer metastases may decrease the uptake and, thus, the effects of anti-tumor drugs. Imatinib, a selective inhibitor of PDGF receptors, and anakinra, an interleukin-1 receptor antagonist, respectively, increase drug uptake and/or decrease IFP in preclinical models of carcinoma. Drug-induced decrease in IFP in human metastases has not been objectively shown, but should be reflected by an increase in water-perfusable tissue fraction (PTF) or tumor blood flow (TBF) using [(15)O]water PET/CT and kinetic modelling. Hence, the aim of this study was to assess the effects of imatinib and anakinra on PTF and TBF in colorectal cancer metastases in patients.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Journal of Nuclear Medicine|
|Publication status||Published - 2015|