The water-perfusable tissue fraction of colorectal cancer metastases is increased by the selective PDGF-receptor inhibitor imatinib but not the IL-1 receptor antagonist anakinra, a study using serial dynamic 15O-water PET.

Research output: Contribution to journalArticle

Abstract

High interstitial fluid pressure (IFP) in colorectal cancer metastases may decrease the uptake and, thus, the effects of anti-tumor drugs. Imatinib, a selective inhibitor of PDGF receptors, and anakinra, an interleukin-1 receptor antagonist, respectively, increase drug uptake and/or decrease IFP in preclinical models of carcinoma. Drug-induced decrease in IFP in human metastases has not been objectively shown, but should be reflected by an increase in water-perfusable tissue fraction (PTF) or tumor blood flow (TBF) using [(15)O]water PET/CT and kinetic modelling. Hence, the aim of this study was to assess the effects of imatinib and anakinra on PTF and TBF in colorectal cancer metastases in patients.

Details

Authors
  • Mark Lubberink
  • Sandeep S V Golla
  • My Jonasson
  • Kristofer Rubin
  • Bengt Glimelius
  • Jens Sörensen
  • Peter Nygren
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Pages (from-to)1144-1149
JournalJournal of Nuclear Medicine
Volume56
Issue number8
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes