The Xg blood group system: no longer forgotten

Research output: Contribution to journalLetter

Abstract

This update of the Xg blood group system (Johnson NC. XG: The forgotten blood group system. Immunohematology 2011;27:68-71) notes the identification of a cis-regulatory element of both XG and CD99 expression, remarkably by two independent groups during 2018, and confirmed by another in 2019. A single nucleotide change at the XG locus (rs311103) abolishes GATA1 binding and suppresses both XG and CD99. The last blood group system to resist elucidation of its genetic basis was thereby resolved. Soon afterwards, it was discovered that the rare anti-Xga response, mainly seen in men, is produced by individuals primarily carrying a large deletion in the X chromosome that truncates XG and leads to the Xgnull phenotype.

Details

Authors
Organisations
External organisations
  • Region Skåne
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics
  • Hematology
Original languageEnglish
Pages (from-to)4-6
Number of pages3
JournalImmunohematology
Volume36
Issue number1
Publication statusPublished - 2020 Jan
Publication categoryResearch
Peer-reviewedNo