Threshold-free high-power methods for the ontological analysis of genome-wide gene expression studies

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Abstract

Ontological analysis facilitates microarray data interpretation. We describe new ontological analysis methods which, unlike existing approaches, are threshold-free and statistically powerful. We perform extensive evaluations and introduce a new concept, detection spectra, to characterize methods. We show that different ontological analysis methods exhibit distinct detection spectra, and that it is critical to account for this diversity. Our results argue strongly against the continued use of existing methods, and provide directions towards an enhanced approach.

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  • Medical Genetics
Original languageEnglish
JournalGenome Biology
Volume8
Issue number5
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes