Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation

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Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation. / Ekdahl, KN; Bengtsson, Anders; Andersson, J; Elgue, G; Ronnblom, L; Sturfelt, Gunnar; Nilsson, B.

In: British Journal of Haematology, Vol. 125, No. 1, 2004, p. 74-78.

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Ekdahl, KN ; Bengtsson, Anders ; Andersson, J ; Elgue, G ; Ronnblom, L ; Sturfelt, Gunnar ; Nilsson, B. / Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation. In: British Journal of Haematology. 2004 ; Vol. 125, No. 1. pp. 74-78.

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TY - JOUR

T1 - Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation

AU - Ekdahl, KN

AU - Bengtsson, Anders

AU - Andersson, J

AU - Elgue, G

AU - Ronnblom, L

AU - Sturfelt, Gunnar

AU - Nilsson, B

PY - 2004

Y1 - 2004

N2 - Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated factor XI-antithrombin complexes and fibrinogen-bound phosphate. All parameters were elevated in SLE patients, particularly those with thrombosis, but normal in DVT cases and healthy controls. We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction of thrombosis.

AB - Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated factor XI-antithrombin complexes and fibrinogen-bound phosphate. All parameters were elevated in SLE patients, particularly those with thrombosis, but normal in DVT cases and healthy controls. We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction of thrombosis.

KW - systemic lupus erythematosus

KW - thrombosis

KW - activation

KW - platelet

KW - beta-thromboglobulin

KW - extracellular phosphorylation

U2 - 10.1111/j.1365-2141.2004.04858.x

DO - 10.1111/j.1365-2141.2004.04858.x

M3 - Article

VL - 125

SP - 74

EP - 78

JO - British Journal of Haematology

T2 - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 1

ER -