Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia AU - Kapur, Rick

Research output: Contribution to journalLetter

Abstract

AbstractImmune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet counts. First-line treatment includes intravenous immunoglobulin (IVIg), however, its working mechanism remains incompletely understood. We investigated splenic and thymic dendritic cell (DC) subsets upon IVIg treatment in a well-characterized active murine model of ITP. During active disease, there was a significant peripheral deficiency of splenic tolerizing SIRPα+ DCs which could be rescued by IVIg therapy, increasing platelet counts. These splenic tolerizing DC changes were associated with an abrogation of the thymic-retention of tolerizing DCs, suggesting that IVIg may raise platelet counts in ITP by modulating peripheral numbers of tolerizing DCs.

Details

Authors
External organisations
  • Saint Michael's Hospital
  • Canadian Blood Services
  • University of Toronto
Original languageEnglish
Pages (from-to)521-524
JournalPlatelets
Volume28
Issue number5
Publication statusPublished - 2017 Jul 4
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes

Bibliographic note

doi: 10.1080/09537104.2016.1246718