Time characteristics of the effect of alcohol cessation on the risk of stomach cancer a meta-analysis

Research output: Contribution to journalArticle

Bibtex

@article{d2521de9655f467e97f9768a9f4ae17d,
title = "Time characteristics of the effect of alcohol cessation on the risk of stomach cancer a meta-analysis",
abstract = "Background: In the Bagnardi et al. (2001) meta-analysis, it was found that alcohol consumption increases the risk of stomach cancer (OR = 1.32 for heavy drinkers). However, it is unknown if drinking cessation reverses this alcohol-elevated risk. Methods: A systematic literature review was performed to provide the information for a meta-analysis where the dose-risk trend was estimated for years since drinking cessation and the risk of stomach cancer. A random effect generalised least squares model for trend estimation was used, employing study characteristics to control for heterogeneity. Results: Nineteen observational studies were identified in the literature review, of which five studies quantified duration of cessation and risk of stomach cancer, giving a total of 1947 cancer cases. No significant effect of drinking cessation on the risk of stomach cancer could be found (OR = 0.99 CI: 0.97-1.02). Conclusions: This result should be interpreted with caution due to the limited number of studies in this area. Recent findings suggest a link between heavy drinking and stomach cancer, especially gastric noncardia, but not for moderate drinking. Since all but one of the included studies in this meta-analysis failed to control for consumption level, the current study could not test if the risk decline following drinking cessation differs between moderate and high consumers.",
keywords = "Alcohol cessation, Stomach cancer, Meta-analysis",
author = "Johan Jarl and Gawain Heckley and Julie Brummer and Ulf Gerdtham",
year = "2013",
doi = "10.1186/1471-2458-13-600",
language = "English",
volume = "13",
journal = "BMC Public Health",
issn = "1471-2458",
publisher = "BioMed Central",

}